G93.41

G93.41: Metabolic encephalopathy

The ICD-10-CM code for encephalopathy that the record attributes to a systemic metabolic derangement rather than to a toxin, to alcohol, to hypertension or to liver disease.

Billable
FY2027

TABLE OF CONTENTS

Medical scribe app interface showing a recording waveform, a list of patient notes, and a SOAP note for John Doe.

Stop looking up codes.

Scribe auto-generates them for you.

Try Commure Scribe →

At a glance

Code Family

G93: Other disorders of brain.

DRG Grouping

MS-DRG 070, 071 or 072 in MDC 01 under the FY2027 MS-DRG v44 grouper, depending on a reported secondary CC or MCC.

HCC Mapping (v28)

None. Code G93.41 does not appear in the CMS-HCC v28 ICD-10-CM mapping for payment year 2026.

Condition

Metabolic encephalopathy

Family Specificity

Subcategory G93.4 holds seven billable codes. Code G93.41 is the only one that names a metabolic cause. The toxic, alcoholic, hypertensive and hepatic forms all sit outside subcategory G93.4.

Billable

Yes, a valid five character code. Its parent G93.4 is a subcategory header and cannot be reported.

Which G93 code do I assign?

Encephalopathy splits on the cause the provider names rather than on severity or acuity. The Alphabetic Index sends the toxic, alcoholic, hypertensive and hepatic forms to codes outside subcategory G93.4, leaving G93.4 to hold the metabolic form, the unspecified form and a short list of named leukoencephalopathies.

When documentation says…
Code
Altered mental status, cause not yet established
R41.82
Altered mental status, unspecified. Code R41.82 carries an Excludes1 note reading altered mental status due to known condition, code to condition. It is displaced as soon as the record names a cause. A change in mental status on its own does not support G93.41. The provider has to document encephalopathy.
Encephalopathy, type not stated
G93.40
Encephalopathy, unspecified. The Alphabetic Index main term Encephalopathy defaults to G93.40, with acute carried as a nonessential modifier. A bare statement of encephalopathy lands here. Query the provider for the cause before moving to G93.41.
Metabolic encephalopathy, or encephalopathy due to hyponatremia
G93.41
Metabolic encephalopathy. The note must carry two things. The first is a provider statement of encephalopathy. The second is a systemic metabolic derangement the encephalopathy is attributed to. Septic encephalopathy is an inclusion term at G93.41 and needs no separate metabolic abnormality.
Toxic metabolic encephalopathy
G92.8
Other toxic encephalopathy. Toxic metabolic encephalopathy is an inclusion term at G92.8. The single documented phrase resolves to one code in category G92. Code G93.41 is not added for that same phrase.
Toxic encephalopathy from cefepime plus metabolic encephalopathy from acute kidney failure
G92.8
Other toxic encephalopathy, reported alongside G93.41. Subcategory G93.4 carries an Excludes2 note for toxic (metabolic) encephalopathy (G92.8), which permits both codes when two separate causes are documented. AHA Coding Clinic, Second Quarter 2024, pages 14 and 15, addresses metabolic encephalopathy reported with toxic metabolic encephalopathy. Code G92.8 also carries a Code first instruction for poisoning due to drug or toxin, at T36-T65 with fifth or sixth character 1 to 4. It carries a Use additional code instruction for an adverse effect, at T36-T50 with fifth or sixth character 5.
Hepatic encephalopathy
K76.82
Hepatic encephalopathy. Code K76.82 carries hepatic encephalopathy NOS and hepatic encephalopathy without coma among its inclusion terms. It carries a Code also instruction for the underlying liver disease. It carries an Excludes1 note for the hepatic failure with coma codes K70.41, K72.01, K72.11 and K72.91. Code G93.41 is not assigned for a hepatic cause.
Delirium due to a known physiological condition
F05
Delirium due to known physiological condition. Code F05 carries a Code first instruction for the underlying physiological condition. Its inclusion terms include acute or subacute confusional state and delirium superimposed on dementia. No Excludes note stands between category F05 and subcategory G93.4. Both may be reported where the record documents both.

Tabular notes

EXCLUDES2

Subcategory G93.4 carries four Excludes2 entries: alcoholic encephalopathy (G31.2), encephalopathy in diseases classified elsewhere (G94), hypertensive encephalopathy (I67.4), and toxic (metabolic) encephalopathy (G92.8). An Excludes2 note means the excluded condition is not part of G93.41. The patient may carry both conditions. Both may be reported where the record documents both. The toxic encephalopathy entry sat under an Excludes1 note before the FY2021 update, which barred that pairing. ACDIS reported the conversion in CDI Strategies, Volume 15, Issue 2, 14 January 2021. No Excludes1 note reaches G93.41 from any level of the tabular.

Chapter 6, Diseases of the nervous system (G00-G99), carries a chapter level Excludes2 list. It includes endocrine, nutritional and metabolic diseases (E00-E88) and symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94). The metabolic derangement that caused the encephalopathy is reported from Chapter 4 alongside G93.41.

FY2027: EFFECTIVE 1 OCTOBER 2026

G93.41 is unchanged in the FY2027 update. The FY2027 tabular addenda add the inclusion term midline shift of brain at G93.5 and change nothing in subcategory G93.4. The FY2026 change that reaches this code sat in the grouper rather than in the tabular. CMS deleted MS-DRGs 077, 078 and 079, reassigned hypertensive encephalopathy (I67.4) into MS-DRGs 070, 071 and 072, and retitled that triplet from Nonspecific Cerebrovascular Disorders to Other Cerebrovascular Disorders.

Operational & financial impact

Why specificity matters beyond the chart: risk adjustment, DRG assignment and denial exposure all follow from which code is selected.

CMS-HCC v28 (PY2024+)

Code G93.41 does not appear in the CMS-HCC v28 ICD-10-CM mapping for payment year 2026. It carries no HCC.

Codes G93.40 and G93.49 carry no CMS-HCC v28 mapping either.

Hepatic encephalopathy (K76.82) does map, to HCC 63, Chronic Liver Failure/End-Stage Liver Disorders.

Hypertensive encephalopathy (I67.4) carries no CMS-HCC v28 mapping.

CMS-HCC v28 is fully phased in at 100 percent for payment year 2026.

MS-DRG v44 (FY2027)

MS-DRG 070: Other Cerebrovascular Disorders with MCC.

MS-DRG 071: Other Cerebrovascular Disorders with CC.

MS-DRG 072: Other Cerebrovascular Disorders without CC/MCC.

All three sit in MDC 01, Diseases and Disorders of the Nervous System.

With G93.41 as the principal diagnosis and no operating room procedure reported, the case groups to MS-DRG 070, 071 or 072.

CMS deleted MS-DRGs 077, 078 and 079 for FY2026 and moved hypertensive encephalopathy (I67.4) into the same triplet. The triplet was titled Nonspecific Cerebrovascular Disorders through FY2025, per the CMS MS-DRG Definitions Manuals v42.0 (FY2025) and v43.0 (FY2026).

A principal diagnosis never acts as its own MCC. Reporting G93.41 first does not by itself produce MS-DRG 070.

Version 44.0 of the grouper applies to discharges on or after 1 October 2026.

Medicare and commercial payers

These MS-DRG rules apply to Medicare Fee for Service inpatient claims.

The CMS-HCC v28 rules apply to Medicare Advantage plans for payment year 2026.

Code G93.41 is complete at five characters and takes no seventh character.

Encephalopathy is reviewed under clinical validation policies that sit alongside the coding rules. The Livanta Claims Review Advisor of October 2022 names encephalopathy as one of the most commonly denied secondary diagnoses in higher weighted DRG audits. Livanta publishes it as a CMS Beneficiary and Family Centered Care Quality Improvement Organization.

WHERE SPECIFICITY IS LOST

Where the record documents altered mental status alone and G93.41 was assigned, the claim reports a diagnosis the provider did not state. The Livanta Claims Review Advisor of October 2022 states that one cannot assume encephalopathy is present just because an alteration in mental status is noted.

Where the provider documented a toxic cause and G93.41 was assigned, the case loses G92.8. The Code first instruction for poisoning and the Use additional code instruction for an adverse effect are lost with it, and with them the substance detail carried by the T codes.

Where the provider documented hepatic encephalopathy and G93.41 was assigned, the case loses K76.82. Code K76.82 maps to HCC 63 under CMS-HCC v28 and G93.41 maps to no HCC at all.

Where the note supports encephalopathy and only R41.82 was assigned, the claim reports a symptom code. Code R41.82 carries an Excludes1 note directing the coder to the condition once the cause is known.

Where severe sepsis is documented and G93.41 was omitted, the claim loses the acute organ dysfunction that subcategory R65.2 instructs the coder to add. Subcategory R65.2 names encephalopathy (metabolic) (septic) (G93.41) in its Use additional code list.

SEVERITY DESIGNATION (MS-DRG V44.0)

G93.41 is an MCC. It appears in Appendix H, diagnoses defined as major complications or comorbidities, in the ICD-10 MS-DRG Definitions Manual Version 44.0. As a secondary diagnosis it can move a case to the with-MCC tier of its DRG pair.

Documentation checklist to support G93.41

Chart elements that support code selection and reduce specificity-driven denials.

FAQ

Is G93.41 a billable code?

Yes. Code G93.41 is a valid five character billable code. Its parent G93.4, other and unspecified encephalopathy, is a subcategory header and cannot be reported on a claim. Category G93 cannot be reported either. Code G93.41 takes no seventh character.

What separates G93.41 from delirium (F05) and from altered mental status (R41.82)?

The three sit at different points on one axis. Code R41.82, altered mental status, unspecified, is a symptom code. It carries an Excludes1 note reading altered mental status due to known condition, code to condition. It is displaced as soon as the record names a cause. Code F05, delirium due to known physiological condition, sits in Chapter 5 and carries a Code first instruction for the underlying physiological condition. Its inclusion terms include acute or subacute confusional state, delirium of mixed etiology, delirium superimposed on dementia and sundowning. Code G93.41 sits in Chapter 6 and carries no Code first instruction. No Excludes note stands between category F05 and subcategory G93.4. Both may be reported where the record documents both.

Does G93.41 map to an HCC under CMS-HCC v28?

No. Code G93.41 does not appear in the CMS-HCC v28 ICD-10-CM mapping for payment year 2026. Codes G93.40 and G93.49 do not appear either. Hepatic encephalopathy (K76.82) does map, to HCC 63, Chronic Liver Failure/End-Stage Liver Disorders. Severity designation under the MS-DRG system and mapping under the risk adjustment model are separate questions and have to be checked separately.

What has to be in the chart to defend G93.41 against a denial?

The chart needs five things. The first is a provider statement of encephalopathy rather than a statement of confusion or altered mental status. The second is the metabolic derangement the provider attributes it to. The third is the patient's baseline mental status and a documented departure from it. The fourth is the same diagnosis and the same type carried consistently through the record. The fifth is treatment and monitoring directed at the condition. The Livanta Claims Review Advisor of October 2022 lists an examination showing altered mental status that is not the patient's baseline, consistent documentation that encephalopathy is present, consistent documentation of its type, and clinical support for that type as the elements reviewers check. The same publication names a record that says the patient was alert and oriented, and a diagnosis introduced only by a post discharge query, as reasons higher weighted DRG claims are changed.

Which code applies when the note says toxic metabolic encephalopathy?

Code G92.8. Toxic metabolic encephalopathy is an inclusion term at G92.8, other toxic encephalopathy. The single documented phrase resolves to one code and G93.41 is not added for it. Where the record instead documents a toxic encephalopathy from one cause and a metabolic encephalopathy from a separate cause, both codes are reported. Subcategory G93.4 carries an Excludes2 note for toxic (metabolic) encephalopathy (G92.8), which permits that pairing. AHA Coding Clinic, Second Quarter 2024, pages 14 and 15, addresses metabolic encephalopathy reported with toxic metabolic encephalopathy. Note that the code is G92.8 rather than G92. Category G92 itself is no longer billable.

Is G93.41 sequenced first, or is the underlying cause?

The tabular does not fix the order. Subcategory G93.4 carries no Code first instruction, and no etiology and manifestation convention applies. Section II of the FY2027 ICD-10-CM Official Guidelines, effective 1 October 2026, defines the principal diagnosis as the condition established after study to be chiefly responsible for occasioning the admission. Where the encephalopathy is what brought the patient in and drove the workup, G93.41 can be sequenced first even where the note says it is due to a urinary tract infection. AHA Coding Clinic, Second Quarter 2018, page 22, addresses that sequencing and puts it on the condition found after study to be responsible for the admission. Two situations override this. Where severe sepsis is documented, the underlying infection is sequenced first, then a code from subcategory R65.2, then G93.41 as the acute organ dysfunction. Where the encephalopathy is integral to another documented condition, such as a postictal state, it is not reported separately at all.

Does G93.41 work the same way on an outpatient claim, and does it still count if the encephalopathy resolves?

The code is the same and the payment rules are not. MS-DRG assignment applies to inpatient claims only. On an outpatient or professional claim G93.41 supports medical necessity and the complexity of medical decision making rather than a DRG. Under Section IV.H of the FY2027 ICD-10-CM Official Guidelines, a diagnosis documented as probable, suspected, questionable or rule out is not coded as confirmed in the outpatient setting. On the inpatient side an uncertain diagnosis documented at discharge may be coded as confirmed under the UHDDS rules. Resolution during the stay does not remove the code. A secondary diagnosis is reportable when it required clinical evaluation, therapeutic treatment, diagnostic procedures, an extended length of stay or increased nursing care. Record the date the mental status returned to baseline rather than leaving a reviewer to infer it.

Does anything change for G93.41 in FY2027?

G93.41 is unchanged in the FY2027 update, effective 1 October 2026. The FY2027 tabular addenda add the inclusion term midline shift of brain at G93.5 and change nothing in subcategory G93.4. The FY2026 change sat in the MS-DRG grouper. CMS deleted MS-DRGs 077, 078 and 079, moved hypertensive encephalopathy (I67.4) into MS-DRGs 070, 071 and 072, and retitled that triplet from Nonspecific Cerebrovascular Disorders to Other Cerebrovascular Disorders. Those are the MS-DRGs a G93.41 principal diagnosis groups to under the FY2027 MS-DRG v44 grouper.

Related codes

Codes in the same family as G93.41. Only codes with a published page render as links.

Sibling codes in the G93 family

  • G93.0: Cerebral cysts.
  • G93.1: Anoxic brain damage, not elsewhere classified.
  • G93.2: Benign intracranial hypertension.
  • G93.31: Postviral fatigue syndrome.
  • G93.32: Myalgic encephalomyelitis/chronic fatigue syndrome.
  • G93.39: Other post infection and related fatigue syndromes.
  • G93.40: Encephalopathy, unspecified.
  • G93.42: Megalencephalic leukoencephalopathy with subcortical cysts.
  • G93.43: Leukoencephalopathy with calcifications and cysts.
  • G93.44: Adult-onset leukodystrophy with axonal spheroids.
  • G93.45: Developmental and epileptic encephalopathy.
  • G93.49: Other encephalopathy.
  • G93.5: Compression of brain.
  • G93.6: Cerebral edema.
  • G93.7: Reye's syndrome.
  • G93.81: Temporal sclerosis.
  • G93.82: Brain death.
  • G93.89: Other specified disorders of brain.
  • G93.9: Disorder of brain, unspecified.

Additional codes to consider

Codes outside the G93 family considered alongside G93.41.

Companion: code alongside when documented

  • R65.20: Severe sepsis without septic shock. Subcategory R65.2 names encephalopathy (metabolic) (septic) (G93.41) in its Use additional code list.
  • R65.21: Severe sepsis with septic shock, under the same R65.2 note.
  • R65.11: Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction, which names G93.41 in its own Use additional code list.
  • M31.11: Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA], which names G93.41 in its Use additional code list.
  • A41.9: Sepsis, unspecified organism, sequenced before the R65.2 code under its Code first note when severe sepsis is documented.
  • E87.1: Hypo-osmolality and hyponatremia, permitted alongside G93.41 by the chapter 6 Excludes2 note for E00–E88.
  • E87.0: Hyperosmolality and hypernatremia, under the same chapter 6 Excludes2 note.
  • E87.20: Acidosis, unspecified, under the same chapter 6 Excludes2 note.
  • R40.20: Unspecified coma, permitted alongside G93.41 by the chapter 6 Excludes2 note for R00–R94.
  • G92.8: Other toxic encephalopathy, where a separate toxic cause is documented alongside the metabolic one, under the Excludes2 note at G93.4.

Consider instead

  • G93.40: Encephalopathy, unspecified, where the provider names no cause.
  • G93.49: Other encephalopathy, where a named form has no code of its own.
  • G92.8: Other toxic encephalopathy, which carries toxic metabolic encephalopathy as an inclusion term.
  • G92.9: Unspecified toxic encephalopathy.
  • G92.0-: Immune effector cell-associated neurotoxicity syndrome, for ICANS following immune effector cellular therapy.
  • K76.82: Hepatic encephalopathy.
  • K72.01: Acute and subacute hepatic failure with coma.
  • K72.91: Hepatic failure, unspecified with coma.
  • I67.4: Hypertensive encephalopathy.
  • G31.2: Degeneration of nervous system due to alcohol, which carries alcoholic encephalopathy as an inclusion term.
  • G94: Other disorders of brain in diseases classified elsewhere, which carries a Code first instruction for the underlying disease.
  • F05: Delirium due to known physiological condition.
  • F10.231: Alcohol dependence with withdrawal delirium.
  • R41.82: Altered mental status, unspecified.
  • R41.0: Disorientation, unspecified, which carries delirium NOS as an inclusion term.
  • E51.2: Wernicke's encephalopathy.
  • E16.2: Hypoglycemia, unspecified, which the Alphabetic Index assigns to hypoglycemic encephalopathy.
  • G93.1: Anoxic brain damage, not elsewhere classified, which the Alphabetic Index reaches from Encephalopathy, hypoxic through Damage, brain, anoxic.
  • P91.60: Hypoxic ischemic encephalopathy [HIE], unspecified, for the newborn.
  • G93.45: Developmental and epileptic encephalopathy.

Sources

All claims on this page derive from government and professional-standards sources.

Stop looking up codes. Scribe generates them for you.

Commure Scribe listens to your visit and auto-generates billing codes, no manual lookup.